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3E-F1D
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The HA present in the skin has a molecular weight of approximately 3000 kDa and is involved in tissue homoeostasis and organisation.
The higher the MW, the greater the water-holding capacity of HA.
Higher MW means greater resistance to degradation by hyaluronidases and thus, a longer half-life.
HA with a MW between 2106 and 4102 kDa fills spaces and can act as a buffer and lubricant.
Inhibits the immune response, inflammation and macrophage phagocytosis.