Universal catalyst which provides good results in a wide spectrum of transformations. High selectivity in cross metathesis (CM) reactions between type 1 olefins (rapid homodimerization, homodimers consumable) and an electron deficient partner. Very good for metathesis with sterically demanding substrates.
Comparison with competing products:
RCM: It is possible to perform the reaction at lower temperature (0 °C). Hoveyda-Grubbs II require higher.
CM: nitro-Grela allows to perform reaction at lower temperature, with lower loading than Grubbs-II and Hoveyda-Grubbs II. The desired products are obtained with higher selectivity.
En-yn: using nitro-Grela gives higher conversion with 2.5 times lower catalyst loading than Hoveyda-Grubbs.