With essential oils and herbal active substances, CocciSafe inhibits oocyste sporulation and interrupts life cycle of coccidia. Compared with coccidiostats, CocciSafe is proved to inhibit intestinal damage and better for weight gain, FCR, and production index in broilers and native chickens. Without drug resistance and residue problem, CocciSafe can replace coccidiostats to prevent and control coccidiosis in poultry.